Sentidos da vulnerabilidade: característica, condição, princípio

Vulnerability is a commonly used term from the current language, particularly in the last decade it has been more frequently used in bioethics discourse. This process resulted in the enunciation of the “respect for human vulnerability” as an ethical principle in the Universal Declaration on Bioethics and Human Rights, from UNESCO, approved in October 2005. In this context there is increasing effort to strictly define the meaning that vulnerability can and must assume, in bioethics field ”“ what we are here trying to contribute to. To reach our objectives, we will start from the etimological concept of the term, as a way to go back to its conceptual origin, we will also take the greatest texts about contemporaneous ethics, in which “vulnerability” is referred in a technical sense and precise way, and we will explore the differ- ent modalities of its evocation in the bioethics field specifying its practical capacity.Vulnerabilidade é um termo comum na linguagem corrente que, principalmente na última década, tem se tornado cada vez mais freqüente no discurso bioético. Este processo culminou com a enunciação do “respeito pela vulnerabilidade humana” como princípio ético na Declaração Universal sobre Bioética e Direitos Humanos, da UNESCO, aprovada em outubro de 2005. Neste contexto, tem aumentado o empenho em definir rigorosamente a significação que a noção de vulnerabilidade pode e deve assumir no domínio específico da bioética ”“ objetivo para o qual queremos contribuir com esta reflexão. Para tal, recuaremos à noção etimológica do termo como fundamento objetivo da sua significação conceitual, retomaremos os grandes textos da reflexão ética contemporânea em que a “vulnerabilidade” é referida com um sentido técnico preciso e exploraremos as diferentes modalidades da sua evocação no âmbito da bioética, especificando igualmente a sua capacidade operativa

How are the portuguese coping with the mandatory confinement by COVID-19?: association between mental health and coping strategies

INTRODUCTION: The global COVID-19 pandemic has had an unprecedented effect on human behaviour and wellbeing. However, researchers have not yet considered how coping responses to stress related to COVID-19 could influence mental health. OBJECTIVES: This study aims to evaluate the mental health status of Portuguese during the national lockdown; examine how study participants cope with stress during the national lockdown; and assess the association between coping and mental health status. METHODS: We cross sectionally analysed data from a convenience sample of 430 adults living in Portugal. Mental health was measured using the five-item Mental Health Inventory. Coping strategies were assessed using the Brief COPE. We examine the univariate associations between mental health status and coping responses. We performed a multiple hierarchical regression analysis controlling for sex and age, to test the predictive importance of coping responses on mental health status. RESULTS: Participants’ mental health was lower than the cut-off point for poor mental health (p<.001). The use of instrumental support, emotional support, self-blame, venting, denial, behavioral disengagement, and substance use were positively significantly associated with mental health, while active coping, positive reframing, acceptance, and humor were negatively significantly associated with mental health. The multiple hierarchical regression analyses showed that sex and age accounted for 6% of the variance of mental health. Coping strategies accounted for an additional and statistically significant 30% of the variance of mental health. CONCLUSIONS: The findings provide support for the impact of the coping strategies on mental health. We encourage future research on the present topic

Do coping responses predict better/poorer mental health in portuguese adults during Portugal's national lockdown associated with the COVID-19?

Background This study aimed at assessing the mental health status of adults living in Portugal during the national lockdown of March 2020 to May 2020, how study participants coped with stress during the national lockdown, as well as the association between coping responses and mental health status. Methods 430 adults from the general population living in Portugal completed measures of mental health status and coping. Results Participants reported a mental health status in the normal range. Most commonly used coping responses were acceptance, planning and active coping. The use of instrumental and emotional support, self-blame, venting, denial, behavioural disengagement, and substance use were associated with poorer mental health. Active coping, positive reframing, acceptance, and humour were associated with better mental health. However, only positive reframing and humour significantly predicted better mental health, while only substance use predicted poorer mental health. Conclusions Findings suggest that there was not a significant negative impact of the Portuguese national lockdown in the adults living in Portugal. Findings supported positive reframing and humour as being adaptive coping responses in this context. These responses should be encouraged by healthcare professionals and targeted in the context of psychosocial intervention programs directed to most vulnerable populations.Fundação para a Ciência e Tecnologia - FCTinfo:eu-repo/semantics/publishedVersio

A feature selection approach for identification of signature genes from SAGE data

<p>Abstract</p> <p>Background</p> <p>One goal of gene expression profiling is to identify signature genes that robustly distinguish different types or grades of tumors. Several tumor classifiers based on expression profiling have been proposed using microarray technique. Due to important differences in the probabilistic models of microarray and SAGE technologies, it is important to develop suitable techniques to select specific genes from SAGE measurements.</p> <p>Results</p> <p>A new framework to select specific genes that distinguish different biological states based on the analysis of SAGE data is proposed. The new framework applies the bolstered error for the identification of strong genes that separate the biological states in a feature space defined by the gene expression of a training set. Credibility intervals defined from a probabilistic model of SAGE measurements are used to identify the genes that distinguish the different states with more reliability among all gene groups selected by the strong genes method. A score taking into account the credibility and the bolstered error values in order to rank the groups of considered genes is proposed. Results obtained using SAGE data from gliomas are presented, thus corroborating the introduced methodology.</p> <p>Conclusion</p> <p>The model representing counting data, such as SAGE, provides additional statistical information that allows a more robust analysis. The additional statistical information provided by the probabilistic model is incorporated in the methodology described in the paper. The introduced method is suitable to identify signature genes that lead to a good separation of the biological states using SAGE and may be adapted for other counting methods such as Massive Parallel Signature Sequencing (MPSS) or the recent Sequencing-By-Synthesis (SBS) technique. Some of such genes identified by the proposed method may be useful to generate classifiers.</p

Predictors and moderators of quality of life in male users of anti-aging products

For most individuals, changes occurring during the aging process may cause dissatisfaction and concerns regarding body image, with implications on quality of life (QoL). The aim of this study was to assess the contribution of sociodemographic and psychological variables and the type of anti-aging products/treatments on men's QoL, as well as to evaluate the moderating role of aging perceptions in the relationship between psychological morbidity and QoL. This study used a cross-sectional design and included a sample of 111 male participants who used anti-aging cosmetic products/aesthetic treatments. Participants were assessed on body image, self-esteem, psychological morbidity, aging perceptions, traits of perfectionism, and QoL. Results suggested that psychological morbidity and perceptions of the aging process as chronic negatively contributed to QoL, and emotional representations of aging moderated the relationship between psychological morbidity and QoL. According to the findings, psychological intervention programs to improve QoL should focus on men with higher levels of psychological morbidity and more negative emotional responses to the aging process.This research was conducted at the Psychological Research Centre (CIPsi/UM), School of Psychology, University of Minho, supported by the Foundation for Science and Technology (FCT) through the Portuguese State Budget (UIDB/01662/2020)

Healthy lifestyle behaviors and the periodicity of mammography screening in brazilian women

INTRODUCTION: Certain behaviors have been associated with health promotion, including mammography screening, in women worldwide. OBJECTIVE: The objective of this study was to determine whether there is an association between the periodicity of mammography screening and healthy lifestyle behaviors in Brazilian women employed at a public university in Bahia, Brazil. METHODS: A total of 635 women of 50–69 years of age at the time of the interview, from the Brazilian Longitudinal Study of Adult Health cohort who were resident in Bahia, participated in the study. Data were collected using a multidimensional questionnaire that included questions on participants’ sociodemographic characteristics and health-related behaviors (smoking, alcohol consumption, leisure-time physical activity and diet) and another questionnaire that dealt with risk factors and breast cancer screening. Measures of association were calculated using simple and multivariate logistic regression. RESULTS: The practice of physical activity, not smoking, moderate alcohol consumption and a healthy diet were the health behaviors most adopted by the women who had last had a mammogram ⩽2 years previously (which is in line with the interval recommended by the Brazilian Ministry of Health). A statistically significant association was found between a lapse of ⩾3 years since last undergoing mammography screening and excessive alcohol consumption, while a borderline association was found between the same screening interval and leisure-time physical inactivity. CONCLUSION: There was an association between lifestyle risk behaviors and a longer time interval between mammography screenings. The present results contribute to the debate on the use of mammography, lifestyle behaviors and health promotion among women

Disparate dispersal limitation in Geomalacus slugs unveiled by the shape and slope of the genetic–spatial distance relationship

Long‐term dispersal ability is a key species’ trait constraining species ranges and thus large‐scale biodiversity patterns. Here we infer the long‐term dispersal abilities of three Geomalacus (Gastropoda, Pulmonata) species from their range‐wide genetic–spatial distance relationships. This approach follows recent advances in statistical modelling of the analogous pattern at the community level: the distance decay in assemblage similarity. While linear relationships are expected for species with high long‐term dispersal abilities, asymptotic relationships are expected for those with more restricted mobility. We evaluated three functional forms (linear, negative exponential and power‐law) for the relationship between genetic distance (computed from mitochondrial cox1 sequences, n = 701) and spatial distance. Range fragmentation at present time and at the Last Glacial Maximum was also estimated based on the projection of climatic niches. The power‐law function best fit the relationship between genetic and spatial distances, suggesting strong dispersal limitation and long‐term population isolation in all three species. However, the differences in slope and explained variance pointed to disparities in dispersal ability among these weak dispersers. Phylogeographic patterns of Geomalacus species are thus largely driven by the same major process (i.e. dispersal limitation), operating at different strengths. This strong dispersal limitation results in geographic clustering of genetic diversity that makes these species highly vulnerable to genetic erosion due to climate changThe authors were supported by the Spanish Ministry of Economy and Competitiveness and the European Regional Development Fund (ERDF) through grant CGL2016‐76637‐P and fellowship IJCI‐2014‐20881 to CG‐RS